Pneumoviridae (taxid:11244)
VIRION
Enveloped, spherical. Diameter from about 150nm nm.
GENOME
Negative-stranded RNA linear genome, about 13-15 kb in size. Encodes for 8 to 11 proteins.
GENE EXPRESSION
The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis.
ENZYMES
- RNA-dependent RNA polymerase [L]
- Mononega-type capping
- RNA TPase, GTase, N7 Mtase, 2'O Mtase [L]
REPLICATION
CYTOPLASMIC
- Virus attaches to host cell surface receptors through HN glycoprotein.
- Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
- Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
- Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
- The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds via the ESCRT complex, releasing the virion.
Host-virus interaction
Inhibition of host Interferon induction
The NS2 protein plays a role in inhibition of RIG-I antiviral signaling
The NS1 protein plays a role in inhibition of MAVS antiviral signaling
Activation of host NF-kappa-B
The HRSV M2-1 can activate NF-kappa-B signaling through interaction with host RELA.
Matching UniProtKB/Swiss-Prot entries
(all links/actions below point to uniprot.org website)116 entries grouped by protein
12 entries
Fusion glycoprotein F0
23 entries
Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)
7 entries
RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase)
9 entries
Protein M2-1 (Envelope-associated 22 kDa protein)
6 entries
Protein M2-2
9 entries
Matrix protein (M protein)
1 entry
Matrix protein
11 entries
Nucleoprotein (Protein N) (Nucleocapsid protein)
8 entries
Non-structural protein 1 (Non-structural protein 1C)
7 entries
Non-structural protein 2 (NS2) (Non-structural protein 1B)
9 entries
Phosphoprotein (Protein P)
11 entries
Small hydrophobic protein (Small protein 1A)
3 entries
Major surface glycoprotein G (Attachment glycoprotein G) (Membrane-bound glycoprotein) (mG)
Canine pneumovirus taxid:1408279
| Protein | ModelArchive |
| Matrix protein M2-2 | ma-jd-viral-61345 |
| Protein M2-1 | ma-jd-viral-32281 |