Peribunyaviridae (taxid:1980416)

VIRION

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Enveloped, spherical. Diameter from 80 to 120nm.

GENOME

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Segmented Negative-stranded RNA linear genome, L segment is between 6.8 and 12 kb, M segment between 3.2 and 4.9 kb and S segment between 1 and 3 kb.
Encodes for four to six proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase (L) bind to a promoter on each encapsidated segment, and transcribes the mRNA. These are capped by L protein during synthesis using cap snatching . Transcription is terminated by a strong hairpin sequence at the end of each gene. Orthobunyavirus express alternative ORF by leaky scanning Phlebovirus and Tospovirus have ambisense segment(s).

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host receptors though Gn-Gc glycoprotein dimer, and is endocytosed into vesicles in the host cell.
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid segments are released in the cytoplasm.
  3. Transcription, viral mRNAs are capped in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsids buds at Golgi apparatus, releasing the virion by exocytosis.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

27 entries grouped by strain

4 entries

Bunyamwera virus (BUNV) reference strain

Select_allDeselect_all
L_BUNYW RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
GP_BUNYW Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...
NSS_BUNYW Non-structural protein NS-S
NCAP_BUNYW Nucleoprotein (Nucleocapsid protein) (Protein N)

4 entries

Bunyavirus La Crosse (isolate Human/United States/L78/1978) reference strain

Select_allDeselect_all
L_BUNL8 RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
GP_BUNL8 Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...
NSS_BUNL8 Non-structural protein NS-S
NCAP_BUNL8 Nucleoprotein (Nucleocapsid protein) (Protein N)

2 entries

Bunyavirus La Crosse reference strain

Select_allDeselect_all
NCAP_BUNLC Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_BUNLC Non-structural protein NS-S

4 entries

Bovine Schmallenberg virus (isolate Bovine/BH80/Germany/2011) (SBV)

Select_allDeselect_all
GP_SBVBH Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...
L_SBVBH RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...
NCAP_SBVBH Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_SBVBH Non-structural protein NS-S

1 entry

Bunyavirus La Crosse

L_BUNLC RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) ...

3 entries

Bunyavirus germiston

Select_allDeselect_all
GP_BUNGE Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...
NSS_BUNGE Non-structural protein NS-S
NCAP_BUNGE Nucleoprotein (Nucleocapsid protein) (Protein N)

3 entries

Bunyavirus snowshoe hare

Select_allDeselect_all
GP_BUNSH Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...
NCAP_BUNSH Nucleoprotein (Nucleocapsid protein) (Protein N)
NSS_BUNSH Non-structural protein NS-S

3 entries

Maguari virus

Select_allDeselect_all
NSS_MAGV Non-structural protein NS-S
NCAP_MAGV Nucleoprotein (Nucleocapsid protein) (Protein N)
Y9KD_MAGV Putative uncharacterized 9.3 kDa protein

2 entries

Aino virus

Select_allDeselect_all
NSS_AINOV Non-structural protein NS-S
NCAP_AINOV Nucleoprotein (Nucleocapsid protein) (Protein N)

1 entry

Bunyavirus La Crosse (isolate Aedes triseriatus/United States/L74/1974)

GP_BUNL7 Envelopment polyprotein (M polyprotein) [Cleaved into: Glycoprotein N (Gn) (Glycoprotein G2); ...
These structures were created with the help of Colabfold by Jason Nomburg, Nathan Price and Jennifer Doudna (ModelArchive).

Brazoran virus taxid:1368616

Protein ModelArchive
Envelopment polyprotein (M polyprotein) ma-jd-viral-57508
Non-structural protein NS-S ma-jd-viral-41302
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-65470

Bunyamwera virus taxid:35304

Protein ModelArchive
Envelopment polyprotein (M polyprotein) ma-jd-viral-57512
Non-structural protein NS-S ma-jd-viral-08150
Non-structural protein NS-S ma-jd-viral-08150
Non-structural protein NS-S ma-jd-viral-08150
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-09399
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-09399
Nucleoprotein (Nucleocapsid protein) (Protein N) ma-jd-viral-09399

Bunyavirus La Crosse (isolate Human/United States/L78/1978) taxid:796210

Protein ModelArchive
Envelopment polyprotein (M polyprotein) ma-jd-viral-57486
Non-structural protein NS-S ma-jd-viral-08171
Nucleoprotein (Nucleocapsid protein) (Protein N) ma-jd-viral-09350

Cat Que virus taxid:1495866

Protein ModelArchive
Envelopment polyprotein (M polyprotein) ma-jd-viral-57521
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-09363

Maprik virus taxid:1590836

Protein ModelArchive
Envelopment polyprotein (M polyprotein) ma-jd-viral-57485
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-09382

Mulberry vein banding virus taxid:1266451

Protein ModelArchive
Envelopment polyprotein (M polyprotein) ma-jd-viral-30767
NSm ma-jd-viral-27533
NSs ma-jd-viral-47174
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-09312

Murrumbidgee virus taxid:1406134

Protein ModelArchive
Envelopment polyprotein (M polyprotein) ma-jd-viral-57489
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-09367

Oropouche virus taxid:118655

Protein ModelArchive
Envelopment polyprotein (M polyprotein) ma-jd-viral-57504
Non-structural protein NS-S ma-jd-viral-08154
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-09394
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-09394
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-09394
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-09394
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-09394
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-09394
Nucleoprotein (Nucleocapsid protein) ma-jd-viral-09394

Shuangao Insect Virus 1 taxid:1608075

Protein ModelArchive
Nucleocapsid protein ma-jd-viral-09341