Orthoavulavirus (taxid:2560194)

VIRION

image

Enveloped, spherical. Diameter from about 150nm nm.

GENOME

image

Negative-stranded RNA linear genome, about 15 kb in size. Encodes for seven proteins.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The V protein is produced through RNA editing of The P mRNA.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachment to host cell surface receptors through HN glycoprotein.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. The ribonucleocapsid binds to the matrix protein and buds via the host ESCRT complexes occurs at the plasma membrane.

Host-virus interaction

Inhibition of host Interferon induction

The V protein plays a role in inhibition of antiviral signaling through STAT1

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

43 entries grouped by strain

8 entries

Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) reference strain

Select_allDeselect_all
HN_NDVB1 Hemagglutinin-neuraminidase (EC 3.2.1.18)
V_NDVB1 Protein V
L_NDVB1 RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
NCAP_NDVB1 Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
FUS_NDVB1 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
W_NDVB1 Protein W
MATRX_NDVB1 Matrix protein
PHOSP_NDVB1 Phosphoprotein (Protein P)

6 entries

Newcastle disease virus (strain Beaudette C/45) (NDV)

Select_allDeselect_all
L_NDVB RNA-directed RNA polymerase L (Protein L) (Large structural protein) (Replicase) (Transcriptase) ...
FUS_NDVB Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_NDVB Hemagglutinin-neuraminidase (EC 3.2.1.18)
NCAP_NDVB Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)
MATRX_NDVB Matrix protein
PHOSP_NDVB Phosphoprotein (Protein P)

4 entries

Newcastle disease virus (strain Chicken/Australia-Victoria/32) (NDV)

Select_allDeselect_all
HN_NDVA Hemagglutinin-neuraminidase (EC 3.2.1.18)
FUS_NDVA Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
MATRX_NDVA Matrix protein
PHOSP_NDVA Phosphoprotein (Protein P) (Non-structural protein C, 38 kDa/29 kDa)

2 entries

Newcastle disease virus (strain B1-Hitchner/47) (NDV)

Select_allDeselect_all
HN_NDVH4 Hemagglutinin-neuraminidase (EC 3.2.1.18)
FUS_NDVH4 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

2 entries

Newcastle disease virus (strain Chicken/Northern Ireland/Ulster/67) (NDV)

Select_allDeselect_all
HN_NDVU Hemagglutinin-neuraminidase (EC 3.2.1.18)
FUS_NDVU Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

2 entries

Newcastle disease virus (strain Chicken/United States(TX)/GB/48) (NDV) (Newcastle disease virus (strain Texas g.b./48))

Select_allDeselect_all
HN_NDVTG Hemagglutinin-neuraminidase (EC 3.2.1.18)
FUS_NDVTG Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

2 entries

Newcastle disease virus (strain Chicken/United States/LaSota/46) (NDV)

Select_allDeselect_all
FUS_NDVL Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_NDVL Hemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain D26/76) (NDV)

Select_allDeselect_all
HN_NDVD Hemagglutinin-neuraminidase (EC 3.2.1.18)
FUS_NDVD Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

2 entries

Newcastle disease virus (strain Her/33) (NDV)

Select_allDeselect_all
FUS_NDVH3 Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_NDVH3 Hemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Italien/45) (NDV)

Select_allDeselect_all
HN_NDVI Hemagglutinin-neuraminidase (EC 3.2.1.18)
FUS_NDVI Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

2 entries

Newcastle disease virus (strain Miyadera/51) (NDV)

Select_allDeselect_all
FUS_NDVM Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]
HN_NDVM Hemagglutinin-neuraminidase (EC 3.2.1.18)

2 entries

Newcastle disease virus (strain Queensland/66) (NDV)

Select_allDeselect_all
HN_NDVQ Hemagglutinin-neuraminidase (EC 3.2.1.18)
FUS_NDVQ Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]

2 entries

Newcastle disease virus (strain Ulster/2C) (NDV)

Select_allDeselect_all
PHOSP_NDVU2 Phosphoprotein (Protein P)
V_NDVU2 Non-structural protein V

1 entry

Newcastle disease virus (isolate AF2240) (NDV)

NCAP_NDVAF Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)

1 entry

Newcastle disease virus (strain Chi/85) (NDV)

HN_NDVC Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Newcastle disease virus (strain Iba/85) (NDV)

HN_NDVJ Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Newcastle disease virus (strain Kansas) (NDV)

HN_NDVK Hemagglutinin-neuraminidase (EC 3.2.1.18)

1 entry

Newcastle disease virus (strain Texas) (NDV)

FUS_NDVT Fusion glycoprotein F0 [Cleaved into: Fusion glycoprotein F2; Fusion glycoprotein F1]