Activation of host caspases by virus

Apoptosis (or programmed cell death) is a controlled process leading to cell death characterized by chromatin condensation, DNA fragmentation, cell shrinkage, and compartimentalization of the dead cells to apoptotic bodies. The host immune system uses apoptosis to eliminate cells infected by pathogens. Apoptosis of infected cells is caused either by cytolytic cells activated during the anti-viral response, or directly by viral infection. Host caspases, constitute an evolutionary conserved family of aspartate-specific cysteine proteases that are at the heart of the apoptotic machinery.

HBX HIVprot NS3 E2 TNF TNFR TRADD FADD CASP8 CASP8 CASP8 FLIP CASP3 CASP3
Viruses from several different families are able to exploit their host’s cell death programmes so as to maximize viral fitness. Apoptosis activation via caspases offers several advantages for viruses. Indeed, it may facilitate progeny virion release after host cell death. Furthermore, during apoptosis, the entire content of the cell, including virions are packaged into membrane-bound apoptotic bodies that are taken by surrounding cells. This process limits the inflammatory response and allow viruses to spread without being detected. HIV protease directly cleaves procaspase-8 to promote apoptosis. HPV 18 E2 protein induces oligomerization of caspase 8 through direct interaction.

Matching UniProtKB/Swiss-Prot entries

43 entries grouped by protein (browse by keywords)

All proteins are shown (view only 25 complete proteome entries)

36 entries

Gag-Pol polyprotein (Pr160Gag-Pol)

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POL_HV1AN
Human immunodeficiency virus type 1 group O (isolate ANT70) (HIV-1) reference strain
POL_HV1B1
Human immunodeficiency virus type 1 group M subtype B (isolate BH10) (HIV-1) reference strain

pdb 1A9M; 1AJV; 1AJX; 1AXA; 1BQM; 1BQN; 1D4H; 1D4I; 1D4J; 1DLO; 1DW6; 1EBK; 1EBW; 1EBY; 1EBZ; 1EC0; 1EC1; 1EC2; 1EC3; 1EET; 1G35; 1GNM; 1GNN; 1GNO; 1HAR; 1HBV; 1HEF; 1HEG; 1HIH; 1HMV; 1HNI; 1HNV; 1HOS; 1HPS; 1HPZ; 1HQE; 1HQU; 1HRH; 1HTE; 1HTF; 1HTG; 1HVI; 1HVK; 1HVP; 1HVU; 1HYS; 1IKV; 1IKW; 1IKX; 1IKY; 1J5O; 1KJH; 1MER; 1MES; 1MET; 1MEU; 1N5Y; 1N6Q; 1NPA; 1NPV; 1NPW; 1QE1; 1QMC; 1R0A; 1RDH; 1RTD; 1RVL; 1RVM; 1RVN; 1RVO; 1RVP; 1RVQ; 1RVR; 1S6P; 1S6Q; 1S9E; 1S9G; 1SBG; 1SUQ; 1SV5; 1T03; 1T05; 1T7K; 1TV6; 1TVR; 1UWB; 1W5V; 1W5W; 1W5X; 1W5Y; 1YT9; 1ZP8; 1ZPA; 1ZSF; 1ZSR; 2AQU; 2B5J; 2B6A; 2BAN; 2BBB; 2BE2; 2EXF; 2G69; 2HB3; 2HMI; 2HNZ; 2HS1; 2HS2; 2I4D; 2I4U; 2I4V; 2I4W; 2I4X; 2I5J; 2IAJ; 2IC3; 2IDW; 2IEO; 2JZW; 2L45; 2L46; 2L4L; 2UXZ; 2UY0; 2VG5; 2VG6; 2VG7; 2X4U; 2YKM; 2YKN; 2ZD1; 2ZE2; 3AVI; 3BGR; 3DLK; 3GGA; 3GGV; 3GGX; 3HVT; 3IG1; 3IRX; 3IS9; 3ISN; 3ITH; 3JSM; 3JYT; 3K2P; 3K4V; 3KLE; 3KLF; 3KLG; 3KLH; 3KLI; 3NDT; 3NU3; 3NU4; 3NU5; 3NU6; 3NU9; 3NUJ; 3NUO; 3OK9; 3PSU; 3QAA; 3QLH; 3QO9; 3TKG; 3TKW; 3TL9; 3TLH; 3V4I; 3V6D; 3V81; 3ZPS; 3ZPT; 3ZPU; 4COE; 4CP7; 4CPQ; 4CPR; 4CPS; 4CPT; 4CPU; 4CPW; 4CPX; 4DG1; 4G1Q; 4G8G; 4G8I; 4G9D; 4G9F; 4H4M; 4H4O; 4I2P; 4I2Q; 4ICL; 4ID5; 4IDK; 4IFV; 4IFY; 4IG0; 4IG3; 4KFB; 4KKO; 4KO0; 4LSL; 4LSN; 4MFB; 4O44; 4O4G; 4OJR; 4PQU; 4PUO; 4PWD; 4Q0B; 4QAG; 4R5P; 4RW4; 4RW6; 4RW7; 4RW8; 4RW9; 4U8W; 4WE1; 4YE3; 4YHQ; 4ZIP; 4ZLS; 5AGZ; 5AH6; 5AH7; 5AH8; 5AH9; 5AHA; 5AHB; 5AHC; 5BRY; 5BS4; 5C24; 5C25; 5C42; 5CYM; 5CYQ; 5D3G; 5FDL; 5HBM; 5HLF; 5HP1; 5HRO; 5I3U; 5I42; 5J1E; 5JFP; 5JFU; 5JG1; 5OI2; 5OI3; 5OI5; 5OI8; 5OIA; 5T6Z; 5T70; 5TEP; 5TER; 5TUQ; 5TW3; 5TXL; 5TXM; 5TXN; 5TXO; 5TXP; 5UFZ; 5ULT; 5UOV; 5UPZ; 5UV5; 5V5L; 5V5M; 5VQQ; 5VQR; 5VQS; 5VQT; 5VQU; 5VQV; 5VQW; 5VQX; 5VQY; 5VQZ; 5W5W; 5YOJ; 6AMO; 6AN2; 6AN8; 6ANQ; 6AOC; 6ASW; 6AVM; 6AVT; 6B19; 6BZ2; 6C0J; 6C0K; 6C0L; 6C0N; 6C0O; 6C0P; 6C0R; 6C8X; 6C8Y; 6CGF; 6D0D; 6D0E; 6DUF; 6DUG; 6DUH; 6ELI; 6HAK; 6OE3

POL_HV1EL
Human immunodeficiency virus type 1 group M subtype D (isolate ELI) (HIV-1) reference strain
POL_HV1ET
Human immunodeficiency virus type 1 group M subtype C (isolate ETH2220) (HIV-1) reference strain
POL_HV1H2
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) reference strain
POL_HV190
Human immunodeficiency virus type 1 group M subtype H (isolate 90CF056) (HIV-1)
POL_HV192
Human immunodeficiency virus type 1 group M subtype C (isolate 92BR025) (HIV-1)
POL_HV193
Human immunodeficiency virus type 1 group M subtype F1 (isolate 93BR020) (HIV-1)
POL_HV196
Human immunodeficiency virus type 1 group M subtype K (isolate 96CM-MP535) (HIV-1)
POL_HV197
Human immunodeficiency virus type 1 group M subtype K (isolate 97ZR-EQTB11) (HIV-1)
POL_HV19N
Human immunodeficiency virus type 1 group M subtype G (isolate 92NG083) (HIV-1)
POL_HV1A2
Human immunodeficiency virus type 1 group M subtype B (isolate ARV2/SF2) (HIV-1)
POL_HV1B5
Human immunodeficiency virus type 1 group M subtype B (isolate BH5) (HIV-1)
POL_HV1B9
Human immunodeficiency virus type 1 group M subtype B (strain 89.6) (HIV-1)
POL_HV1BR
Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1)
POL_HV1JR
Human immunodeficiency virus type 1 group M subtype B (isolate JRCSF) (HIV-1)
POL_HV1LW
Human immunodeficiency virus type 1 group M subtype B (isolate LW123) (HIV-1)
POL_HV1M2
Human immunodeficiency virus type 1 group M subtype F2 (isolate MP257) (HIV-1)
POL_HV1MA
Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1)
POL_HV1MN
Human immunodeficiency virus type 1 group M subtype B (isolate MN) (HIV-1)
POL_HV1MP
Human immunodeficiency virus type 1 group M subtype F2 (isolate MP255) (HIV-1)
POL_HV1MV
Human immunodeficiency virus type 1 group O (isolate MVP5180) (HIV-1)
POL_HV1N5
Human immunodeficiency virus type 1 group M subtype B (isolate NY5) (HIV-1)
POL_HV1ND
Human immunodeficiency virus type 1 group M subtype D (isolate NDK) (HIV-1)
POL_HV1OY
Human immunodeficiency virus type 1 group M subtype B (isolate OYI) (HIV-1)
POL_HV1RH
Human immunodeficiency virus type 1 group M subtype B (isolate RF/HAT3) (HIV-1)
POL_HV1S2
Human immunodeficiency virus type 1 group M subtype J (isolate SE9280) (HIV-1)
POL_HV1S9
Human immunodeficiency virus type 1 group M subtype J (isolate SE9173) (HIV-1)
POL_HV1SE
Human immunodeficiency virus type 1 group M subtype G (isolate SE6165) (HIV-1)
POL_HV1U4
Human immunodeficiency virus type 1 group M subtype A (isolate U455) (HIV-1)
POL_HV1V9
Human immunodeficiency virus type 1 group M subtype H (isolate VI991) (HIV-1)
POL_HV1VI
Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1)
POL_HV1Y2
Human immunodeficiency virus type 1 group M subtype B (isolate YU-2) (HIV-1)
POL_HV1YB
Human immunodeficiency virus type 1 group N (isolate YBF106) (HIV-1)
POL_HV1YF
Human immunodeficiency virus type 1 group N (isolate YBF30) (HIV-1)
POL_HV1Z2
Human immunodeficiency virus type 1 group M subtype D (isolate Z2/CDC-Z34) (HIV-1)

1 entry

Genome polyprotein

POLG_LANVT
Langat virus (strain TP21)

1 entry

Tyrosine phosphatase H2 (PTP-H2) (EC 3.1.3.48)

PTPH2_MDBVW
Microplitis demolitor bracovirus (isolate Webb) (MdBV) reference strain

5 entries

Small hydrophobic protein (Small protein 1A)

Select_allDeselect_all
SH_HRSVA
Human respiratory syncytial virus A (strain A2) reference strain
SH_HRSVB
Human respiratory syncytial virus B (strain B1) reference strain
SH_HRSS2
Human respiratory syncytial virus A (strain S-2) (HRSV-S2)
SH_HRSV1
Human respiratory syncytial virus B (strain 18537)
SH_HRSV8
Human respiratory syncytial virus B (strain 8/60)