Bornaviridae (taxid:178830)

VIRION

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Enveloped, spherical. Diameter from 70 to 130 nm.

GENOME

Negative-stranded RNA linear genome, about 8.9 kb in size. Encodes for six proteins to 9 proteins.

Enzymes: RNA dependent RNA polymerase, RNA guanylyl transferase, mRNA methyltransferase.

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. the third transcript encodes M, G and L by alternative splicing.

ENZYMES

REPLICATION

NUCLEAR

  1. Attachement of the viral GP glycoproteins to host receptors mediates Clathrin-mediated endocytosis of the virus into the host cell
  2. Fusion of virus membrane with the vesicle membrane; ribonucleocapsid is released and migrates to the nucleus.
  3. Sequential transcription, viral mRNAs are capped and polyadenylated by polymerase stuttering in the cytoplasm. M, G and L proteins are produced by alternative splicing.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
  5. Neo-synthesized ribo-nucleocapsids exit out of the nucleus by nuclear pore export.
  6. Cytoplasmic ribo-nucleocapsids bind to the matrix protein under cell membrane, inducing particle budding.
  7. Release of new virions.

Host-virus interaction

Apoptosis modulation

The bornavirus X protein has been shown to play a role both for viral replication and apoptosis modulation

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

12 entries grouped by protein

2 entries

RNA-directed RNA polymerase L (Protein L) (EC 2.7.7.48) (Large structural protein) (Replicase) (Transcriptase)

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L_BDV1
Borna disease virus 1 (BoDV-1) reference strain
L_BDVV
Borna disease virus (strain V) (BDV) reference strain

2 entries

Matrix protein (gp18) (p16)

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MATRX_BDV1
Borna disease virus 1 (BoDV-1) reference strain
MATRX_BDVV
Borna disease virus (strain V) (BDV) reference strain

2 entries

Nucleoprotein (N protein) (Nucleocapsid protein) (p38) (p40)

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NCAP_BDV1
Borna disease virus 1 (BoDV-1) reference strain
NCAP_BDVV
Borna disease virus (strain V) (BDV) reference strain

2 entries

Phosphoprotein (P protein) (p23) (p24)

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PHOSP_BDV1
Borna disease virus 1 (BoDV-1) reference strain
PHOSP_BDVV
Borna disease virus (strain V) (BDV) reference strain

2 entries

Envelope glycoprotein p57 (gp84) (gp94)

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VGLG_BDV1
Borna disease virus 1 (BoDV-1) reference strain
VGLG_BDVV
Borna disease virus (strain V) (BDV) reference strain

2 entries

X protein (p10)

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X_BDVV
Borna disease virus (strain V) (BDV) reference strain
X_BDV1
Borna disease virus 1 (BoDV-1)