Narmovirus

VIRION

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Enveloped, spherical. Diameter of about 150 nm.

GENOME

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Negative-stranded RNA linear genome, from 15 to 17 kb in size. Encodes for eight proteins.
Enzymes: RNA dependent RNA polymerase, RNA guanylyl transferase, mRNA methyltransferase

GENE EXPRESSION

The viral RNA dependent RNA polymerase binds the encapsidated genome at the leader region, then sequentially transcribes each genes by recognizing start and stop signals flanking viral genes. mRNAs are capped and polyadenylated by the L protein during synthesis. The V protein is expressed by mRNA editing of the P messenger.

REPLICATION

CYTOPLASMIC

  1. Virus attaches to host cell surface receptors through HN, H or G glycoproteins.
  2. Fusion with the plasma membrane; ribonucleocapsid is released in the cytoplasm.
  3. sequential transcription, viral mRNAs are capped and polyadenylated in the cytoplasm.
  4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthesized antigenomes and genomes.
  5. The ribonucleocapsid interacts with the matrix protein under the plasma membrane and buds, releasing the virion.

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

4 entries grouped by strain (browse by keywords)

4 entries

Tupaia paramyxovirus (TPMV) reference strain

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PHOSP_TPMV Phosphoprotein (Protein P)
C_TPMV Protein C
V_TPMV Non-structural protein V
NCAP_TPMV Nucleoprotein (Nucleocapsid protein) (NP) (Protein N)