Fimoviridae (taxid:1980412)

VIRION

Enveloped, spherical.

GENOME

The genome is segmented and consists of four segments of linear negative-sense and single-stranded RNA. The complete genome is around 12.2 kb.

GENE EXPRESSION

The viral RNA dependent RNA polymerase (L) binds to a promoter on each encapsidated segment, and transcribes the mRNAs. These are capped by L protein during synthesis using cap snatching

ENZYMES

• RNA-dependent RNA polymerase [L]
• Cap Snatching endonuclease [L]

REPLICATION

CYTOPLASMIC

1. Virus attaches to host receptors.
2. Fusion of virus membrane with the cell membrane; ribonucleocapsid segments are released in the cell.
3. Transcription, viral mRNAs are capped in the cytoplasm.
4. Replication presumably starts when enough nucleoprotein is present to encapsidate neo-synthetized antigenomes and genomes.
5. The ribonucleocapsids buds from a cellular membrane, releasing the virion.