Spinareoviridae (taxid:2946187)

VIRION

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Rotavirus maturation schemes

Non enveloped, icosahedral virion with a double capsid structure (except for cypoviruses and dinovernaviruses which have only the equivalent of the inner capsid). The outer capsid has a T=13 icosahedral symmetry, the inner capsid a T=2* icosahedral symmetry.
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GENOME

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Segmented linear dsRNA genome. Contains 10 to 12 segments coding for 10 to 14 proteins. Segments size range from 0.2 to 3.0 kb. Genome total size range from 18.2 to 30.5 kb.

GENE EXPRESSION

The dsRNA genome is never completely uncoated to prevent activation of antiviral state by the cell in response to dsRNA. Viral polymerase synthesizes mRNA from each of the dsRNA segments. These mRNAs are translocated to the cell cytoplasm where they are translated.
Further proteins are produced by leaky scanning and protein processing.

ENZYMES

REPLICATION

CYTOPLASMIC

  1. Attachement to host receptors probably mediates endocytosis of virus into host cell.
  2. Particles are partially uncoated in endolysosomes, but not entirely, and penetrate in the cytoplasm.
  3. Early transcription of the dsRNA genome by viral polymerase occurs inside this sub-viral particle (naked core), so that dsRNA is never exposed to the cytoplasm.
  4. Transcription from each of the dsRNA segments produces mRNA templates for translation.
  5. Viral proteins and genomic RNAs aggregates in cytoplasmic viral factories.
  6. (+)RNAs are encapsidated in a sub-viral particle, in which they are transcribed to give RNA (-) molecules with which they become base-paired to produce dsRNA genomes.
  7. The capsid is assembled on the sub-viral particle.
  8. Mature virions are released presumably following cell death and associated breakdown of host plasma membrane.

Host-virus interaction

Apoptosis modulation

Mammalian reovirus mediates host cell apoptosis through the activation of death receptors, including TRAIL, TNFR and Fas . Activation of these death receptors induces the activation downstream caspases (caspase-3)

Avian orthoreovirus induces host cell apoptosis probably through upregulation of p53 (activation of DNA-damage signalling) by viral sigmaC protein .

Autophagy modulation

Avian orthoreovirus also seems to induces autophagy .

Innate immune response inhibition

Avian orthoreovirus σA protein binds to dsRNA and inhibits the PRK-mediated antiviral response of the host cell .
Mammalian orthoreoreovirus σ3 protein binds to dsRNA and inhibits the PRK-mediated antiviral response of the host cell .
Mammalian orthoreovirus &mu2; protein from strain Lang (T1L) inhibits IFN-beta-induced reporter gene expression .

Matching UniProtKB/Swiss-Prot entries

(all links/actions below point to uniprot.org website)

142 entries grouped by protein

8 entries

Major inner capsid protein VP3 (EC 3.6.4.13) (ATP-dependent DNA helicase VP3)

Select_allDeselect_all
CAPSD_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain

Putative major capsid protein VP3

CAPSD_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
CAPSD_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain
CAPSD_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

Putative major capsid protein

CAPSD_LDCPR
Lymantria dispar cypovirus 1 (isolate Rao) (LdCPV-1) reference strain

Major capsid protein VP1

CAPSD_RRSVT
Rice ragged stunt virus (isolate Thailand) (RRSV) reference strain

Major inner capsid protein VP3 (Major core capsid protein VP3)

CAPSD_AQRVA
Aquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)
CAPSD_CPVBM
Bombyx mori cytoplasmic polyhedrosis virus (BmCPV)

Capsid protein VP1

3 entries

Inner capsid protein lambda-1 (Lambda1) (EC 3.6.4.13) (ATP-dependent DNA helicase lambda-1) (Lambda1(Hel))

Select_allDeselect_all
LMBD1_REOVJ
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) reference strain
LMBD1_REOVL
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) reference strain
LMBD1_REOVD
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

3 entries

Outer capsid protein lambda-2 (Lambda2) (Lambda2(Cap))

Select_allDeselect_all
LMBD2_REOVJ
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) reference strain
LMBD2_REOVL
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) reference strain
LMBD2_REOVD
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

3 entries

Outer capsid protein mu-1 (Mu1)

Select_allDeselect_all
MU1_REOVJ
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) reference strain
MU1_REOVL
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) reference strain
MU1_REOVD
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

3 entries

Microtubule-associated protein mu-2 (Mu2)

Select_allDeselect_all
MU2_REOVJ
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) reference strain
MU2_REOVL
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) reference strain
MU2_REOVD
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

3 entries

Protein mu-NS (MuNS)

Select_allDeselect_all
MUNS_REOVJ
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) reference strain
MUNS_REOVL
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) reference strain
MUNS_REOVD
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

1 entry

Movement and RNA silencing protein VP6

MVP_RRSVT
Rice ragged stunt virus (isolate Thailand) (RRSV) reference strain

1 entry

Non-structural protein 1 (NS1)

NS1_LDCPR
Lymantria dispar cypovirus 1 (isolate Rao) (LdCPV-1) reference strain

1 entry

Non-structural protein 3 (NS3)

NS3_LDCPR
Lymantria dispar cypovirus 1 (isolate Rao) (LdCPV-1) reference strain

1 entry

Non-structural protein 5 (NS5)

NS5_LDCPR
Lymantria dispar cypovirus 1 (isolate Rao) (LdCPV-1) reference strain

5 entries

Polyhedrin (C-polyhedrin)

Select_allDeselect_all
PYHD_LDCPR
Lymantria dispar cypovirus 1 (isolate Rao) (LdCPV-1) reference strain

Polyhedrin

PYHD_CPVBM
Bombyx mori cytoplasmic polyhedrosis virus (BmCPV)
PYHD_CPVCS
Choristoneura fumiferana cypovirus (CfCPV) (Choristoneura fumiferana cytoplasmic polyhedrosis virus)
PYHD_CPVES
Euxoa scandens cypovirus (EsCPV) (Euxoa scandens cytoplasmic polyhedrosis virus)
PYHD_CPVOP
Orgyia pseudotsugata cypovirus (OpCPV) (Orgyia pseudotsugata cytoplasmic polyhedrosis virus)

12 entries

RNA-directed RNA polymerase VP2 (EC 2.7.7.48)

Select_allDeselect_all
RDRP_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain
RDRP_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
RDRP_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain
RDRP_CTFVL
Colorado tick fever virus (strain USA/Florio N-7180) (CTFV) reference strain

RNA-directed RNA polymerase VP1 (EC 2.7.7.48)

RDRP_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

RNA-directed RNA polymerase VP1 (EC 2.7.7.48)

RDRP_LDCPR
Lymantria dispar cypovirus 1 (isolate Rao) (LdCPV-1) reference strain
RDRP_MYRV9
Cryphonectria parasitica mycoreovirus 1 (strain 9B21) (CpMYRV-1) reference strain

RNA-directed RNA polymerase VP1 (EC 2.7.7.48)

RDRP_REOVJ
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) reference strain

RNA-directed RNA polymerase lambda-3 (Lambda3) (EC 2.7.7.48) (Lambda3(Pol))

RDRP_REOVL
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) reference strain

RNA-directed RNA polymerase lambda-3 (Lambda3) (EC 2.7.7.48) (Lambda3(Pol))

RDRP_RRSVT
Rice ragged stunt virus (isolate Thailand) (RRSV) reference strain

RNA-directed RNA polymerase (EC 2.7.7.48)

RDRP_AQRVA
Aquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)
RDRP_REOVD
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

RNA-directed RNA polymerase lambda-3 (Lambda3) (EC 2.7.7.48) (Lambda3(Pol))

1 entry

Uncharacterized protein S10

S10_DPIRV
Diadromus pulchellus idnoreovirus 1 (DpIRV-1)

1 entry

Uncharacterized protein S2

S2_DPIRV
Diadromus pulchellus idnoreovirus 1 (DpIRV-1)

1 entry

Uncharacterized protein S3

S3_DPIRV
Diadromus pulchellus idnoreovirus 1 (DpIRV-1)

1 entry

Uncharacterized protein S3bis

S3BIS_DPIRV
Diadromus pulchellus idnoreovirus 1 (DpIRV-1)

1 entry

Uncharacterized protein S7

S7_DPIRV
Diadromus pulchellus idnoreovirus 1 (DpIRV-1)

1 entry

Uncharacterized protein S8

S8_DPIRV
Diadromus pulchellus idnoreovirus 1 (DpIRV-1)

1 entry

Uncharacterized protein S9

S9_DPIRV
Diadromus pulchellus idnoreovirus 1 (DpIRV-1)

3 entries

Protein sigma-1-small (Sigma1s) (Sigma-s) (Sigma1NS) (Sigma1bNS) (p14)

Select_allDeselect_all
SIG1S_REOVJ
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) reference strain
SIG1S_REOVL
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) reference strain
SIG1S_REOVD
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

1 entry

Sigma-C capsid protein (Sigma-3 protein)

SIGC_ARVS1
Avian reovirus (strain S1133) (ARV)

3 entries

Outer capsid protein sigma-1 (Sigma1) (Cell attachment protein) (Hemagglutinin)

Select_allDeselect_all
SIGM1_REOVJ
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) reference strain
SIGM1_REOVL
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) reference strain
SIGM1_REOVD
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

3 entries

Inner capsid protein sigma-2 (Sigma2)

Select_allDeselect_all
SIGM2_REOVJ
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) reference strain
SIGM2_REOVL
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) reference strain
SIGM2_REOVD
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

3 entries

Outer capsid protein sigma-3 (Sigma3)

Select_allDeselect_all
SIGM3_REOVJ
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) reference strain
SIGM3_REOVL
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) reference strain
SIGM3_REOVD
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

3 entries

Protein sigma-NS (SigmaNS)

Select_allDeselect_all
SIGNS_REOVJ
Reovirus type 2 (strain D5/Jones) (T2J) (Mammalian orthoreovirus 2) reference strain
SIGNS_REOVL
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1) reference strain
SIGNS_REOVD
Reovirus type 3 (strain Dearing) (T3D) (Mammalian orthoreovirus 3)

2 entries

Non-structural protein 1 (NS1)

Select_allDeselect_all
VNS1_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
VNS1_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

Non-structural protein 1 (NS1) (NS73)

2 entries

Non-structural protein 2 (NS2)

Select_allDeselect_all
VNS2_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
VNS2_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

2 entries

Non-structural 3 (NS3) (NS26)

Select_allDeselect_all
VNS3_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain

Non-structural protein 3 (NS3)

VNS3_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

2 entries

Non-structural protein 4 (NS4)

Select_allDeselect_all
VNS4_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
VNS4_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

Non-structural protein 4 (NS4) (NS31)

2 entries

Non-structural protein 5 (NS5)

Select_allDeselect_all
VNS5_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
VNS5_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

Non-structural protein 5 (NS5) (NS16)

5 entries

Outer capsid protein VP1

Select_allDeselect_all
VP1_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain

Putative structural protein VP1

VP1_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain
VP1_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain
VP1_RRSVT
Rice ragged stunt virus (isolate Thailand) (RRSV) reference strain

Structural protein VP1

VP1_AQRVA
Aquareovirus A (isolate Chum salmon/Japan/CSRV/1981) (AQRV-A)

5 entries

Microtubule-associated protein VP10

Select_allDeselect_all
VP10_CTFVL
Colorado tick fever virus (strain USA/Florio N-7180) (CTFV) reference strain
VP10_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

Putative outer capsid protein p10

VP10_MYRV9
Cryphonectria parasitica mycoreovirus 1 (strain 9B21) (CpMYRV-1) reference strain

Uncharacterized protein VP10

VP10_RRSVT
Rice ragged stunt virus (isolate Thailand) (RRSV) reference strain

Non-structural protein VP10

VP10_RBSDV
Rice black streaked dwarf virus (RBSDV)

Protein S10

2 entries

Uncharacterized protein VP11

Select_allDeselect_all
VP11_CTFVL
Colorado tick fever virus (strain USA/Florio N-7180) (CTFV) reference strain
VP11_MYRV9
Cryphonectria parasitica mycoreovirus 1 (strain 9B21) (CpMYRV-1) reference strain

1 entry

Uncharacterized protein VP12

VP12_CTFVL
Colorado tick fever virus (strain USA/Florio N-7180) (CTFV) reference strain

3 entries

Outer capsid protein VP2

Select_allDeselect_all
VP2_CTFVL
Colorado tick fever virus (strain USA/Florio N-7180) (CTFV) reference strain

Putative RNA methyltransferase VP2 (EC 2.1.1.-)

VP2_MYRV9
Cryphonectria parasitica mycoreovirus 1 (strain 9B21) (CpMYRV-1) reference strain

Uncharacterized protein VP2

VP2_RRSVT
Rice ragged stunt virus (isolate Thailand) (RRSV) reference strain

4 entries

Putative structural protein VP3

Select_allDeselect_all
VP3_CTFVL
Colorado tick fever virus (strain USA/Florio N-7180) (CTFV) reference strain

Uncharacterized protein VP3

VP3_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain
VP3_LDCPR
Lymantria dispar cypovirus 1 (isolate Rao) (LdCPV-1) reference strain
VP3_MYRV9
Cryphonectria parasitica mycoreovirus 1 (strain 9B21) (CpMYRV-1) reference strain

Outer capsid protein VP3

7 entries

Uncharacterized protein VP4

Select_allDeselect_all
VP4_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain

Putative non-structural protein 4 (NS4)

VP4_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain

Outer capsid protein VP4

VP4_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

Outer capsid protein VP4

VP4_CTFVL
Colorado tick fever virus (strain USA/Florio N-7180) (CTFV) reference strain
VP4_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain
VP4_LDCPR
Lymantria dispar cypovirus 1 (isolate Rao) (LdCPV-1) reference strain

Outer capsid protein VP4

VP4_MYRV9
Cryphonectria parasitica mycoreovirus 1 (strain 9B21) (CpMYRV-1) reference strain

1 entry

Uncharacterized protein VP4b

VP4B_RRSVT
Rice ragged stunt virus (isolate Thailand) (RRSV) reference strain

8 entries

Uncharacterized protein VP5

Select_allDeselect_all
VP5_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain

Outer capsid protein VP5

VP5_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain

Microtubule-associated protein VP5

VP5_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

Microtubule-associated protein VP5

VP5_CTFVL
Colorado tick fever virus (strain USA/Florio N-7180) (CTFV) reference strain
VP5_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain
VP5_LDCPR
Lymantria dispar cypovirus 1 (isolate Rao) (LdCPV-1) reference strain

Putative structural protein VP5

VP5_MYRV9
Cryphonectria parasitica mycoreovirus 1 (strain 9B21) (CpMYRV-1) reference strain
VP5_RRSVT
Rice ragged stunt virus (isolate Thailand) (RRSV) reference strain

Putative minor structural protein VP5

7 entries

Microtubule-associated protein VP6

Select_allDeselect_all
VP6_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain
VP6_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain

Clamp protein VP6

VP6_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

Clamp protein VP6

VP6_CTFVL
Colorado tick fever virus (strain USA/Florio N-7180) (CTFV) reference strain

Uncharacterized protein VP6

VP6_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

Uncharacterized protein VP6

VP6_LDCPR
Lymantria dispar cypovirus 1 (isolate Rao) (LdCPV-1) reference strain
VP6_MYRV9
Cryphonectria parasitica mycoreovirus 1 (strain 9B21) (CpMYRV-1) reference strain

1 entry

Probable non-structural 41.0 kDa protein

VP61_MRDV
Maize rough dwarf virus (MRDV)

1 entry

Probable non-structural 36.3 kDa protein

VP62_MRDV
Maize rough dwarf virus (MRDV)

6 entries

Uncharacterized protein VP7

Select_allDeselect_all
VP7_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain
VP7_AQRVC
Aquareovirus C (isolate Golden shiner/USA/GSRV/1977) (AQRV-C) reference strain

Outer capsid protein VP7

VP7_AQRVG
Aquareovirus G (isolate American grass carp/USA/PB01-155/-) (AQRV-G) reference strain

Outer capsid protein VP7

VP7_CTFVL
Colorado tick fever virus (strain USA/Florio N-7180) (CTFV) reference strain
VP7_MYRV9
Cryphonectria parasitica mycoreovirus 1 (strain 9B21) (CpMYRV-1) reference strain
VP7_RRSVT
Rice ragged stunt virus (isolate Thailand) (RRSV) reference strain

Microtubule-associated protein VP7

1 entry

Uncharacterized protein VP7-1

VP71_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

1 entry

Uncharacterized protein VP7-2

VP72_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

5 entries

Uncharacterized protein VP8

Select_allDeselect_all
VP8_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain
VP8_CTFVL
Colorado tick fever virus (strain USA/Florio N-7180) (CTFV) reference strain
VP8_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

Microtubule-associated protein VP8

VP8_MYRV9
Cryphonectria parasitica mycoreovirus 1 (strain 9B21) (CpMYRV-1) reference strain
VP8_RRSVT
Rice ragged stunt virus (isolate Thailand) (RRSV) reference strain

Structural protein precursor VP8

4 entries

Structural protein VP9

Select_allDeselect_all
VP9_APRVF
Aedes pseudoscutellaris reovirus (isolate France) (ApRV) reference strain

Uncharacterized protein VP9

VP9_CTFVL
Colorado tick fever virus (strain USA/Florio N-7180) (CTFV) reference strain
VP9_MYRV9
Cryphonectria parasitica mycoreovirus 1 (strain 9B21) (CpMYRV-1) reference strain

Uncharacterized protein VP9

VP9_RRSVT
Rice ragged stunt virus (isolate Thailand) (RRSV) reference strain

1 entry

Non-structural protein P9-1

VP91_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

1 entry

Uncharacterized protein VP9-2

VP92_FDVS
Fiji disease virus (isolate Sugarcane) (FDV) reference strain

1 entry

Non structural protein VP9'

VP9P_CTFVL
Colorado tick fever virus (strain USA/Florio N-7180) (CTFV) reference strain